To view a list of articles and abstracts that have been published by or about Chemokine Therapeutics, please refer to the tables below.
Publications by Chemokine Scientists
| Authors | Title | Citation | |
|---|---|---|---|
| 1) | Su Young Kim, Chih Hung Lee, Brieanne V. Midura, Choh Yeung, Arnulfo Mendoza, Sung Hyeok Hong, Ling Ren, Donald Wong, Walter Korz, Ahmed Merzouk, Hassan Salari, Hong Zhang, Sam T. Hwang, Chand Khanna, Lee J. Helman | Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastases | Clin. Exp. Med. |
| 2) | David K Jin, Koji Shido, Hans-Georg Kopp, Isabelle Petite, Sergey V Shmelkov, Lauren M Young, Andrea T Hooper, Hideki Amano, Scott T Avecilla, Beate Heissig, Koichi Hattori, Fan Zhang, Daniel J Hicklin, Yan Wu, Zhenping Zhu, Ashley Dunn, Hassan Salari, Zena Werb, Neil R Hackett, Ronald G Crystal, David Lyden, Shahin Rafii | Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4 hemangiocytes | Nature Medicine. 2006 May;12(5):557-567 |
| 3) | Pelus LM, Bian H, Fukuda S, Wong D, Merzouk A, Salari H. | The CXCR4 agonist peptide, CTCE-0021, rapidly mobilizes polymorphonuclear neutrophils and hematopoietic progenitor cells into peripheral blood and synergizes with granulocyte colony-stimulating factor. | Exp Hematol. 2005 Mar;33(3):295-307. |
| 4) | Zhong R, Law P, Wong D, Merzouk A, Salari H, Ball ED. | Small peptide analogs to stromal derived factor-1 enhance chemotactic migration of human and mouse hematopoietic cells. | Exp Hematol. 2004 May;32(5):470-5. |
| 5) | Tudan C, Willick GE, Chahal S, Arab L, Law P, Salari H, Merzouk A. | C-terminal cyclization of an SDF-1 small peptide analogue dramatically increases receptor affinity and activation of the CXCR4 receptor. | J Med Chem. 2002 May 9;45(10):2024-31. |
| 6) | Perez LE, Alpdogan O, Shieh JH, Wong D, Merzouk A, Salari H, O'Reilly RJ,van den Brink MR, Moore MA. | Increased plasma levels of stromal-derived factor-1 (SDF-1/CXCL12) enhance human thrombopoiesis and mobilize human colony-forming cells (CFC) in NOD/SCID mice. | Exp Hematol. 2004 Mar;32(3):300-7. |
| 7) | Loetscher P, Gong JH, Dewald B, Baggiolini M, Clark-Lewis I. | N-terminal peptides of stromal cell-derived factor-1 with CXC Chemokine receptor 4 agonist and antagonist activities. | J Biol Chem. 1998 Aug 28;273(35):22279-83. |
Articles on Chemokine Receptors and Cancer
| Authors | Title | Citation | Subject | |
|---|---|---|---|---|
| 1) | Kim S.Y., Lee C.H., Midura B.V., Yeung C., Mendoza A., Hong S.H., Wong D., Korz W., Merzouk A., Salari H., Zhang H., Hwang S.T., Khanna C., Helman L.J. | CTCE-9908 inhibits metastasis in osteosarcoma and melanoma models | Clin Exp Met. Online first. | CTCE-9908 paper in cancer. |
| 2) | Balkwill F. | Cancer and the chemokine network | Nat Rev Cancer 4:540, 2004. | Classic review on chemokines in cancer. |
| 3) | Slettenaar V.I.F., Wilson J.L. | The chemokine network: A target in cancer biology? | Adv Drug Deliv Rev 58:962, 2006. | Review on chemokines in cancer. |
| 4) | Raman D., Baugher P.J., Thu Y.M., Richmond A. | Role of chemokines in tumor growth | Can Lett 256:137, 2007. | Review on chemokines in different types of cancers. |
| 5) | Koizumi K., Hojo S., Akashi T., Yasumoto K., Saiki I. | Chemokine receptors in cancer metastasis and cancer cell-derived chemokines in host immune response | Can Sci 98(11):1652, 2007. | Review on chemokines in metastasis. |
| 6) | Aghi M., Cohen K.S., Klein R.J., Scadden D.T., Chiocca E.A. | Tumor Stromal-Derived Factor-1 Recruits Vascular Progenitors to Mitotic Neovasculature, where Microenvironment Influences Their Differentiated Phenotypes | Can Res 66(18):9054, 2006. | Vasculogenesis (blood vessel formation from bone marrow cells) and cancer. SDF-1 and CXCR4 in recruitment of endothelial progenitor cells (bone marrow cells). |
| 7) | Rafii S., Lyden D. | A Few to Flip the Angiogenic Switch | Science 319:163, 2008. | CXCR4, vasculogenesis (blood vessel formation from bone marrow cells) and cancer metastasis. Short comment. |
| 8) | Schminski C.C., Bahre R., Gockel I., Muller A., Frerich K., Horner V., Teufel A., Simiantonaki N., Biesterfeld S., Wehler T., Schuler M., Achenbach T., Junginger T., Galle P.R., Moehler M. | Dissemination of hepatocellular carcinoma is mediated via chemokine receptor CXCR4 | Br J Cancer 95:210, 2006. | Liver cancer metastasis and CXCR4. |
| 9) | Sutton A., Friand V., Brule-Donneger S., Chaigneau T., Ziol M., Sainte-Catherine O., Poire A., Saffar L., Kraemer M., Vassy J., Nahon P., Salzmann J.-L., Gattegno L., Charnaux N. | Stromal Cell-Derived Factor-1/Chemokine (C-X-C Motif) Ligand 12 StimulatesHu man Hepatoma Cell Growth, Migration, and Invasion | Mol Can Res 5(1):21, 2007. | Liver cancer and the SDF-1/CXCR4 pathway. |
| 10) | Kryczek I., Lange A., Mottram P., Alvarez X., Cheng P., Hogan M., Moons L., Wei S., Zou L., Machelon V., Emilie D., Terrassa M., Lackner A., Curiel T.J., Carmeliet P., Zou W. | CXCL12 and Vascular Endothelial Growth Factor Synergistically Induce Neoangiogenesis in Human Ovarian Cancers | Can Res 65(2):465, 2005. | Ovarian cancer and SDF-1. |
| 11) | Muller A., Homey B., Soto H., Ge N., Catron D., Buchanan M.E., McClanahan T., Murphy E., Yuan W., Wagner S.N., Barrerak J.L., Mohark A., Verasteguik E., Zlotnik A. | Involvement of chemokine receptors in breast cancer metastasis | Nature 410:50, 2001. | Original article describing role of CXCR4 in breast cancer metastasis model. |
| 12) | Murphy P.M. | Chemokines and the molecular basis of cancer metastasis | New Engl J Med 345(11) :833, 2001. | Comment on Muller article above. |
| 13) | Luker K.E., Luker D.E. | Functions of CXCL12 and CXCR4 in breast cancer | Cancer Lett 238:30, 2006. | The SDF-1/CXCR4 pathway in breast cancer. Review. |
| 14) | Darash-Yahana M., Pikarsky E., Abramovitch R., Zeira E., Pal B., Karplus R., Beider K., Avniel S., Kasem S., Galun E., Peled A. | Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis | FASEB J 18:1240, 2004. | CXCR4 in prostate cancer - growth, vascularization and metastasis. |
Publications on chemokines and hematopoiesis
| Authors | Title | Citation | |
|---|---|---|---|
| 1) | Avecilla ST, Hattori K, Heissig B, Tejada R, Liao F, Shido K, Jin DK, Dias S, Zhang F, Hartman TE, Hackett NR, Crystal RG, Witte L, Hicklin DJ, Bohlen P, Eaton D, Lyden D, de Sauvage F, Rafii S. | Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis. | J Biol Chem. 1998 Aug 28;273(35):22279-83. |
American Association for Cancer Research, 99th Annual Meeting, April 2008
Targeting CXCR4 inhibits primary tumor growth and distant metastasis in a transgenic breast cancer mouse model. Hassan S.
A pilot study assessing the utility of cytokines as surrogate endpoints in therapy directed against chemokine mediated metastasis. Hotte SJ.
Blockade of therapy-induced acute recruitment of bone marrow-derived CXCR4+Flt-1+ hemangiocytes inhibits hypoxia-induced tumor angiogenesis in hepatocellular carcinoma. Poon RTP.
Inhibition of the SDF1/CXCR4 pathway - translational research to clinical development. Tolcher AW.
AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics conference, 2007
Phase I/II study of CTCE-9908, a novel anticancer agent that inhibits CXCR4, in patients with advanced solid cancers. Hotte SJ.
Blockade of chemokine receptor CXCR4 for the treatment of hepatocellular carcinoma metastasis. Kok TW.
Anti cancer effect of a combination of CXCR4 antagonist CTCE-9908 and Docetaxel in a murine model of human prostate cancer. Wong D.
American Association for Cancer Research, 98th Annual Meeting, April 2007
Inhibition of primary tumor growth and distant metastasis with a CXCR4 antagonist in a mouse model of breast cancer. Huang EH.
Characterization of the anti-metastatic activity of a SDF-1 peptide analog in different tumor models. Leung E.
Pediatric Academic Societies' Annual Meeting, 2006
CXCR4 Inhibition Leads to Decreased Adhesion and Fewer Metastases in Osteosarcoma. Kim SY.
American Association for Cancer Research, 97th Annual Meeting, April 2006
In vitro and in vivo effects of CXCR4 inhibition in osteosarcoma. Kim SY.
A peptide antagonist of chemokine receptor CXCR4 reduces tumor metastasis in a murine orthotopic model of human prostate cancer. Wong D.
Miami Nature Biotechnology Winter Symposium, 2006
The CXCR4 antagonist CTCE-9908 inhibits SDF-1-induced angiogenesis. Leung E.
Blood and Marrow Transplantation Tandem Meetings, February 2006
A Stromal Cell Derived Factor 1 (SDF-1) Agonist Stimulates Neutrophil Mobilization in Normal Humans after Subcutaneous Injection. Wong D.
American Association for Cancer Research, 96th Annual Meeting, April 2005
Inhibition of Murine Osteosarcoma Lung Metastases Using the CXCR4 Antagonist, CTCE-9908. Kim SY.
American Society of Hematology, 45th Annual Meeting, December 2004
Short Pulse of a Small Peptide Agonist of Stromal Cell-Derived Factor-1 (SDF-1) Enhances the Engraftment of Expanded Human Cord Blood Hematopoietic Progenitor Cells in NOD/SCID Mice. Li K.
American Society of Hematology, 45th Annual Meeting, December 2003
Enhancement of Chemotaxis Migration of CD34+ Human Stem Cells in Vitro and Mobilization of Lineage Negative, SCA-1+, C-KIT+ Mouse Hematopoietic Stem Cells in Vivo By Stromal Cell Derived Factor-1 (SDF-1) Agonists. Zhong R.
A small peptide analog of stromal derived factor-1 (SDF-1) enhances survival and expansion of cord blood (CB) CD34+ cells in synergy with cytokines. K. Li Increase of Blood Neutrophils by A Peptide Analog to Stromal Derived Factor-1 (SDF-1). Law P.
IAIS World Congress on Inflammation, 2003
A novel Chemokine (stromal cell-derived factor-1, SDF-1) peptide agonist is a potent chemotactic factor for polymorphonuclear leukocyte (PMN) in vitro and induces rapid PMN migration in vivo. Wong D.
American Association for Cancer Research, 94th Annual Meeting, July 2003
Analogs of Stromal Cell Derived Factor 1 (SDF-1) sharply reduce chemotherapeutic drug induced neutropenia. Wong D.
American Society of Hematology, 44th Annual Meeting, December 2002
Plasma-Stable Analogs of Chemokine SDF-1 Have Potent Hematopoietic Activity In Vivo and In Vitro. Wong D.
CTCE-21, a Peptide Agonist of Stromal Cell-Derived Factor-1 alpha (SDF-1), Rapidly Mobilizes Polymorphonuclear Neutrophils (PMN) and Hematopoietic Stem and Progenitor Cells Following Single Administration and Synergizes with G-CSF for Both Effects. Pelus LM.
Enhancement of chemotaxis migration of CD34+ hematopoietic stem cells and dendritic cells by a CXCR4 ligand-CTCE-021. Zhong R.
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